alexa Abstract | Development and Evaluation of Polyherbal Tablet Formulation with Potent Anti-Inflammatory and COX-2 Inhibitory Activity

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The main objective of the present study was to develop a polyherbal solid dosage formulation and to evaluate antiinflammatory activity with specific COX-2 inhibitory activity. Based on the available traditional and scientific literature, plants that possess anti-inflammatory activity were selected. The extracts were prepared by successive soxhlation using solvents like petroleum ether, chloroform, ethyl acetate, methanol and water. In vitro evaluation of the extracts was done by HRBC membrane stabilisation method using diclofenac sodium as standard to study the anti-inflammatory activity. In vitroCOX-2 inhibitory activity of the same extracts was evaluated by enzyme immunoassay method. Herbal tablets were prepared by direct compression method by using the fractions with potential COX-2 inhibitory activity obtained by fractionation of the active extracts by column chromatography. Five tablet formulations with varying concentration of the active fractions of various herbs were prepared and standardised. All the formulations were further studied for specific COX-2 inhibitory activity among which, Polyherbal formulation IV proved to show pronounced invitro COX-2 inhibitory activity.

To read the full article Peer-reviewed Article PDF image

Author(s): Nasreen Begum Srisailam K and Uma Maheshwararao V


Polyherbal tablet, COX-2 inhibitory activity, HRBC membrane stabilisation, enzyme immunoassay, Anti-Inflammatory

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version