alexa Abstract | Development and validation of a reverse phase HPLC method for the simultaneous estimation of Metoprolol and Telmisartan in tablet dosage form

Der Pharmacia Sinica
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Research Article Open Access

Abstract

Present work describes a simple, accurate, precise and reproducible reverse phase High Performance Liquid Chromatographic method for simultaneous estimation of Metoprolol and Telmisartan in tablet dosage form on RP C-18 Column ( Hypersil Gold, 25cm x 4.6mm, 5μm) using Acetonitrile and buffer (0.05M KH2PO4, pH 3.0±0.02, 35:65 v/v) as mobile phase at a flow rate of 1.0 ml/min and the detection wavelength was 225nm. The retention time for Metoprolol and Telmisartan was found to be 3.71 and 10.02 min. respectively. Detection response for both Metoprolol and Telmisartan were found to be linear low in concentration range of 29.88-69.72mcg/ml and 24.12-56.27mcg/ml respectively in the linearity study, regression equation and coefficient of correlation for Metoprolol and Telmisartan were found to be (y = 33409x + 5518, r2 =0.9999) and (y = 111545x – 5850.4, r2 = 0.9999). Proposed method was validated for accuracy, precision, linearity, range, ruggedness & robustness.

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Author(s): Joshi Pryanka and Kumar Mukesh

Keywords

Metoprolol, Telmisartan, RP- HPLC, U.V.

 
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