alexa Abstract | Development and Validation of a Reversed Phase HPLC Method for Simultaneous Estimation of Enalapril maleate, Hydrochlorothiazide and Paracetamol in Pure and its Pharmaceutical Dosage Form

Der Pharmacia Sinica
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Research Article Open Access


A simple, reproducible and efficient reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for estimation of Enalapril Maleate, (EM), Hydrochlorothiazide (HCT) and Paracetamol in its pure and tablet dosage form. The mobile phase consisting of acetonitrile: water (pH 4.7 adjusted with ortho phosphoric acid) in the ratio of (25:75%v/v) was delivered at the flow rate of 1.2 mL/min and detection was carried out at 220 nm. The separation was achieved using C18 reverse phase column ( Hi-Q 250x4.6mm ID; particle size 5μm).The validation of method carried out as per ICH guidelines. The method was tested for linearity, accuracy, recovery study and specificity.

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Author(s): Pratap Y Pawar Rupali S Joshi Kunal N Jangale Santosh K Wagh Vijay P Sandhan

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