alexa Abstract | Development and validation of a simultaneous HPTLC method for the estimation of olmesartan medoxomil and hydrochlorothiazide in tablet dosage form

Indian Journal of Pharmaceutical Sciences
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Abstract

A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the estimation of olmesartan medoxomil and hydrochlorothiazide simultaneously in combined dosage forms. The stationary phase used was precoated silica gel 60F 254 . The mobile phase used was a mixture of acetonitrile:chloroform:glacial acetic acid (7:2:0.5, v/v/v). The detection of spots was carried out at 254 nm. The method was validated in terms of linearity, accuracy, precision and specificity. The calibration curve was found to be linear between 500 to 750 ng/spot for olmesartan medoxomil and 100 to 600 ng/spot for hydrochlorothiazide. The limit of detection and the limit of quantification for the olmesartan medoxomil were found to be 170 and 500 ng/spot, respectively and for hydrochlorothiazide 30 and 100 ng/spot, respectively. The proposed method can be successfully used to determine the drug content of marketed tablet formulation.

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Author(s): NJ Shah BN Suhagia RR Shah NM Patel

 
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