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Original Articles Open Access
A specific and accurate HPLC method is developed for the determination of pazopanib in bulk drugs and in solid tablet dosage form. Best symmetric peak shape obtained with Phenomenox Kinetex -C18 (100 X 4.6 mm, 2.6μ) column in an isocratic mode, with retention time 20min.The mobile phase used was potassium dihydrogen phosphate buffer : Methanol 60:40(v/v) with flow rate 0.8 ml/min and wavelength monitored at 263 nm. As per ICH guidelines method has validated. Method has found linear in the range of 5-45 μg/ml. The LOD and LOQ were found to be 0.05 and 0.1 μg/ml respectively. Method was found specific with respective of diluents, excipients and degradants.
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Author(s): Kishore Kumar Reddy Y J Raveendra Reddy and N Devanna
Pazopanib (PPB), Limit of Detection (LOD), Limit of quantitation (LOQ), pharmaceutical dosage form