alexa Abstract | Development and Validation of a Stability-indicating UV Spectroscopic Method for Candesartan in Bulk and Formulations

Indian Journal of Pharmaceutical Sciences
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Abstract

A simple, specific, accurate and stability-indicating UV- Spectrophotometric method was developed for the estimation of candesartan cilexitil, using a Shimadzu, model 1700 spectrophotometer and a mobile phase composed of methanol: water in the ratio of 9:1 at wave length (λmax) 254 nm. Linearity was established for candesartan in the range of 10- 90 μg/ml. The percentage recovery of was found to be in the range of 99.76-100.79%. The drug was subjected to acid, alkali and neutral hydrolysis, oxidation, dry heat, UV light and photolytic degradation. Validation experiments performed to demonstrate system suitability, specificity, precision, linearity, accuracy, interday assay, intraday assay, robustness, ruggedness, LOD, and LOQ. While estimating the commercial formulation there was no interference of excipients and other additives. Hence this method can be used for routine determination of candesartan cilexetil in bulk and their pharmaceutical dosage forms. The proposed method for stability study shows that there was appreciable degradation found in stress condition of candesartan.

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Author(s): KK Pradhan US Mishra S Pattnaik CK Panda KC Sahu

Keywords

Analytical method, Candesartan cilexetil, degradation, UV Spectroscopy, validation

 
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