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Original Articles Open Access
A simple, precise, accurate and specific high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of Telmisartan and Indapamide in pharmaceutical solid dosage form without separation of components. The method is based on high performance thin layer chromatographic separation of both drugs followed by the densitometric measurements at 249 nm. The separation was carried out on precoated silica gel 60 GF254 using mobile phase hexane: ethyl acetate: methanol: glacial acetic acid (14:6:2:1 v/v/v/v) with Rf values 0.21 and 0.36 for Telmisartan and Indapamide respectively. The calibration curve was found to be linear between 2000-7000 ng/spot for Telmisartan and 75-262.5 ng/spot for Indapamide with correlation co-efficient 0.9970 and 0.9959 respectively. It was observed that the proposed HPTLC method could be used for efficient analysis and monitoring of the Telmisartan and Indapamide in combined pharmaceutical solid dosage forms.
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Author(s): Dipen K Sureja Ghanshyam R Parmar Mehul M Patel and Kantilal R Vadalia
Telmisartan, Indapamide, Simultaneous estimation, HPTLC, HPTLC