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A simple liquid chromatographic method was developed and validated for determination of sumatriptan succinate (SUMA) in tablet dosage form. The analysis is performed at ambient temperature on a reversed-phase C18 column with detection at 232 nm. The mobile phase consisting of ACN : Water (18:82) and 0.05% v/v trifluro acetic acid was added in water at a constant flow rate of 1.0 ml/min. The method was validated for accuracy, precision, linearity and specificity. The linearity was found to be in the range of 10-50 ppm. The % recovery was found between the range of 98.0% to 102.0% of the labeled value. The proposed method was successfully applied for the routine quantitative analysis of tablets containing SUMA
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Author(s): SOLANKI SAGAR D DR PATEL PARESH U DRSUHAGIYA BHANUBHAI N
Sumatriptan succinate, HPLC.