alexa Abstract | Development and validation of RP-HPLC-PDA method for the analysis of Citalopram hydrobromide in bulk, dosage forms and in in vitro dissolution samples

Journal of Chemical and Pharmaceutical Research
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Abstract

The objective of the current work is to develop a simple, efficient, economical and LC-MS compatible RP-HPLCPDA method for the analysis of Citalopram Hydrobromide in bulk, dosage forms and in dissolution samples. Samples were separated on Agilent Eclipse C18 column (150 x 4.6mm, 5μm) with mobile phase composed of 10mM Ammonium acetate: methanol (35:65 v/v) in isocratic mode. The detection wavelength was fixed at 239nm. The retention time of Citalopram Hydrobromide was 3.1min and the method showed a good linearity in the concentration range of 5-25μg/mL with a correlation coefficient of 0.997. The method was validated for specificity, linearity, limit of detection, limit of quantification, precision, robustness and stability. All the validation parameters were within the compendial requirements. The proposed method was successfully adopted for the analysis of Citalopram Hydrobromide in bulk, pharmaceutical dosage forms and in dissolution samples.

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Author(s): CH Ajay Kumar A Prabhakar Reddy G Lakshmi Suneetha M Sai Sree M Vijaya Lakshmi and Buchi N Nalluri

Keywords

Citalopram Hydrobromide, Agilent Eclipse C18 column, Dissolution Studies, PDA Detection, Method Validation., Citalopram hydrobromide

 
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