alexa Abstract | Development and validation of stability indicating HPTLC method for simultaneous estimation of paracetamol and mefenamic acid in liquid dosage form

Journal of Chemical and Pharmaceutical Research
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Abstract

A simple, accurate, precise and selective stability- indicating high performance thin layer chromatographic method has been developed and validated for simultaneous estimation of Paracetamol and Mefenamic acid in suspension. Chromatographic separation of both the drugs was achieved by using Benzene: Methanol (8.5: 1.5, v/v) as mobile phase with UV detection at 226 nm. The retention factors for Paracetamol and Mefenamic acid were found to be 0.39 ± 0.006 and 0.69± 0.006, respectively. The developed method was validated in terms of linearity, accuracy, precision and robustness as per ICH guidelines. The drugs were subjected to stress condition of hydrolysis (acid, base), oxidation. Linear response was observed in the concentration range of 250-1500 ng band-1 for Paracetamol and 100-600 ng band-1 for Mefenamic acid. The method has been applied for the analysis of drugs in suspension. The % assay (Mean ± S.D.) was found to be 99.00 ± 1.48 for Paracetamol and 99.84± 1.87 for Mefenamic acid.

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Author(s): Yogesh Gandhi Padmanabh Deshpande Neha Deore and Ganesh Sarowar

Keywords

Paracetamol, Mefenamic acid, HPTLC, Stress degradation, Validation, HPTLC

 
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