alexa Abstract | Development and validation of UV spectrophotometric method for the determination of pazopanib hydrochloride in bulk and tablet formulation

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The present work discuss the development and validation of a simple, accurate and cost efficient UV spectrophotometric method for Pazopanib hydrochloride (PAZ).The optimum conditions and solvents for the analysis of the drug were established through scouting trails using different solvent compositions. PAZ showed maximum sensitivity, good percent recovery, good spectral properties in methanol compared to other solvent/solvent mixtures. Absorption maxima (λ max) of PAZ was found to be 214nm in methanol. The percentage recovery of PAZ was found to be 99.69±0.873. Beers law was obeyed in the concentration range of 5.5-7.5μg/mL and calibration curve has shown a linear relationship between the absorbance and concentration with in this range. The line equation Y = 0.2016x - 0.5804 with R2 of 0.9933 was obtained from the linearity studies. Validation was performed according to ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method can be used for the analysis of Pazopanib hydrochloride in bulk and tablet formulation for quality control purposes.

To read the full article Peer-reviewed Article PDF image

Author(s): G Chaitanya and A K M Pawar


Pazopanib hydrochloride, UV spectrophotometric method, ICH Analytical Method Validation, Tablets.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version