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Original Articles Open Access
The present work discuss the development and validation of a simple, accurate and cost efficient UV spectrophotometric method for Pazopanib hydrochloride (PAZ).The optimum conditions and solvents for the analysis of the drug were established through scouting trails using different solvent compositions. PAZ showed maximum sensitivity, good percent recovery, good spectral properties in methanol compared to other solvent/solvent mixtures. Absorption maxima (λ max) of PAZ was found to be 214nm in methanol. The percentage recovery of PAZ was found to be 99.69±0.873. Beers law was obeyed in the concentration range of 5.5-7.5μg/mL and calibration curve has shown a linear relationship between the absorbance and concentration with in this range. The line equation Y = 0.2016x - 0.5804 with R2 of 0.9933 was obtained from the linearity studies. Validation was performed according to ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method can be used for the analysis of Pazopanib hydrochloride in bulk and tablet formulation for quality control purposes.
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Author(s): G Chaitanya and A K M Pawar
Pazopanib hydrochloride, UV spectrophotometric method, ICH Analytical Method Validation, Tablets.