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A rapid, simple, selective and precise UV- Visible Spectrophotometric method has been developed for the determination of Curcumin in bulk forms and solid dosage formulations. The spectrophotometric detection was carried out at an absorption maximum of 421 nm using methanol as solvent. The method was validated for specificity, linearity, accuracy, precision, robustness and ruggedness. The detector response for the Curcumin was linear over the selected concentration range 1 to 7 μg/ml with a correlation coefficient of 0.9995. The accuracy was between 99.1& 101.4%. The precision (R.S.D.) among six sample preparations was 0.39%. The LOD and LOQ are 0.05 and 0.172 μg/ml, respectively. The recovery of curcumin was about 100.4 %. The results demonstrated that the excipients in the commercial tablets did not interfere with the method and can be conveniently employed for routine quality control analysis of Curcumin in bulk drug, marketed tablets and other formulations.
UV- Visible Spectrophotometer, Curcumin, ICH guidelines