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NH-Hydrochloride (NH) is a selective 5-HT1 agonist developed for the acute treatment of migraine which acts by stimulating constriction of dilated cranial arteries and by inhibiting the release of neurogenic inflammatory mediators. A simple, sensitive, precise, accurate and economical UV-Spectrophotometric method has been developed for the determination of NH in bulk and pharmaceutical dosage form. Absorption for NH was measured at maximum wavelength 281nm. The percentage recovery of NH in pharmaceutical dosage form was found to be 99.43 to 98.53 %. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 2-10μg/ml having line equation y = 0.019x with correlation coefficient of 0.99. Results of the analysis were validated according to the ICH guidelines. The results obtained were statistically evaluated and were found to be accurate and reproducible. The proposed method can be successfully applied for the estimation of Naratriptan Hydrochloride in bulk and pharmaceutical dosage form.
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Author(s): Santosh Shelke Sadhana Shahi Vandana Patil Suwarna Kale
Naratriptan Hydrochloride (NH), migraine, economical, UV-Spectrophotometric method, pharmaceutical dosage form