alexa Abstract | Development and validation of UV-Spectrophotometric method for determination of Cefuroxime Axetil in bulk and in Formulation

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

A simple, rapid, accurate and economical UVspectrophotometric method has been developed for estimation of Cefuroxime axetil from bulk and pharmaceutical formulation. The λmax of Cefuroxime axetil in 0.1N HCL was found to be 281 nm. The drug follows linearity in the concentration range 0.4 - 2 μg/ml with correlation coefficient value 0.998. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 99.19 % was found in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 80%, 100% and 120 %. The % recovery was found to be in the range 98.54%– 99.98%. The low values of % R.S.D. are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 2 indicate that the method is precise. Ruggedness of the proposed method was studied with the help of two analysts. The above method was a rapid and cost-effective quality-control tool for routine analysis of Cefuroxime axetil in bulk and in pharmaceutical dosage form.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Jain Pritam Patel Manish Surana Sanjay

Keywords

Cefuroxime axetil, UV, validation, quantitative determination.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords