alexa Abstract | Development, Evaluation and Characterization of surface solid dispersion for solubility and dissolution enhancement of Irbesartan

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The objective of the present study was to formulate Surface solid dispersions (SSD) of Irbesartan to improve the solubility and dissolution rate to facilitate faster onset of action. Irbesartan is a BCS-II drug having low solubility and low availability. In the present study, SSD’s of Irbesartan with four different superdisintegrants (Crospovidone, Croscarmellose sodium, Sodium starch glycolate, Pre-gelatinized starch) with five different drug-carrier ratios were prepared by solvent evaporation method. SSD’s were characterized by assay & content uniformity, FT-IR studies, PXRD (Powder X- ray diffractometry, DSC (differential scanning calorimetry), Gas chromatography and in vitro dissolution studies. The dissolution profile of prepared dispersion of Irbesartan: SSG in 1:7 ratio were faster compared to other carriers, DSC studies revealed that there was no interaction between drug: carrier where as the PXRD demonstrated that there was a significant decrease in crystallinity of pure drug present in the surface solid dispersions, which resulted in an increased dissolution rate of Irbesartan.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Anand Kumar Meka Santhosh Pola Karnaker Reddy Tupally Prasanna LakshmiAbbaraju

Keywords

Irbesartan, Surface solid dispersion, superdisintegrants

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords