alexa Abstract | Development, Evaluation and Characterization of surface solid dispersion for solubility and dissolution enhancement of Irbesartan

International Journal of Drug Development and Research
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The objective of the present study was to formulate Surface solid dispersions (SSD) of Irbesartan to improve the solubility and dissolution rate to facilitate faster onset of action. Irbesartan is a BCS-II drug having low solubility and low availability. In the present study, SSD’s of Irbesartan with four different superdisintegrants (Crospovidone, Croscarmellose sodium, Sodium starch glycolate, Pre-gelatinized starch) with five different drug-carrier ratios were prepared by solvent evaporation method. SSD’s were characterized by assay & content uniformity, FT-IR studies, PXRD (Powder X- ray diffractometry, DSC (differential scanning calorimetry), Gas chromatography and in vitro dissolution studies. The dissolution profile of prepared dispersion of Irbesartan: SSG in 1:7 ratio were faster compared to other carriers, DSC studies revealed that there was no interaction between drug: carrier where as the PXRD demonstrated that there was a significant decrease in crystallinity of pure drug present in the surface solid dispersions, which resulted in an increased dissolution rate of Irbesartan.

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Author(s): Anand Kumar Meka Santhosh Pola Karnaker Reddy Tupally Prasanna LakshmiAbbaraju


Irbesartan, Surface solid dispersion, superdisintegrants

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