alexa Abstract | Development, Formulation and Evaluation of Atomoxetine Oral Films

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Fast-dissolving drug delivery system offers solution for the problems related to patient compliance especially in the case of geriatric and paediatric population. Atomoxetine is a selective nor epinephrine re-uptake inhibitor. It is used for the treatment of attention-deficit hyperactivity disorder (ADHD). The objective of formulating atomoxetine oral films is to provide rapid dissolution of drug and absorption which may produce the rapid onset of action and also to improve the bioavailability of the drug. Oral films were developed and prepared by solvent evaporation method. The film forming agent used was hydroxypropyl methylcellulose (HPMC) and propylene glycol as a plasticizer. A standard calibration curve was established with the maximum absorption at 269 nm. Further the evaluation of the film was done through a series of tests like thickness, weight variation, in vitro dispersion time and pH, drug content determination and drug – excipient compatibility by FT-IR. The mechanical properties of the developed films (tensile strength, % elongation, folding endurance) were also found to be in acceptable limits. Hence, atomoxetine oral dispersing film was formulated and evaluated which results in the development of the product with higher efficacy and bio availability.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Mamatha Tirunagari Syed Ahmed Anitha Nandagopal

Keywords

Atomoxetine, hydroxypropyl methylcellulose, in vitro dispersion, and oral films

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords