alexa Abstract | Development of a HPLC method for the simultaneous determination of losartan potassium and atenolol in tablets

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access

Abstract

A new reversed-phase high performance liquid chromatography method was developed and validated for the simultaneous determination of losartan potassium and atenolol in tablets. The separation was achieved on Supelcosil ODS analytical column (25×0.46 cm, i.d., 5 µm) using acetonitrile and 25 mM potassium dihydrogen phosphate (45:55 v/v, pH 3.00±0.05) as mobile phase at a flow rate of 1.2 ml/min. Detection was carried out using a UV detector at 227 nm. The method was validated. The developed and validated method was successfully applied for the quantitative analysis of Losar beta® tablets. The total chromatographic analysis time per sample was about 6 min with atenolol, chlorzoxazone (internal standard) and losartan eluting at retention times of about 2.72, 4.89 and 5.61 min, respectively. The standard curves were linear over the concentration ranges, 1 to 10 µg/ml for losartan potassium and atenolol. The values obtained of LODs were 0.029 and 0.062 µg/ml and LOQs were 0.078 and 0.187 µg/ml for losartan potassium and atenolol, respectively. The proposed method is fast, accurate and precise for the determination of losartan potassium and atenolol for routine quality control of tablets containing these two drugs.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): T Sivakumar P Venkatesan R Manavalan K Valliappan

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords