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The aim of the present study is to develop colon targeted drug delivery systems for Trimetazidine Hcl using sodium alginate as a carrier. In this study, investigation of an oral colon specific, pulsatile device to achieve time or site specific release of Trimetazidine, based on chronopharmaceutical considerations. The basic design consists of an insoluble hard gelatin capsule body, filled with sodium alginate microsphere of trimetazidine and sealed with a hydrogel plug. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The trimetazidine microsphere were prepared, evaluated for the FTIR study, surface morphology, particle size, drug content, and from the obtained results one better formulation was selected for further fabrication of pulsatile capsule. Different concentration of the hydrogel polymers were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. FTIR study confirmed that there was no interaction between drug and polymer, the shape of microsphere was found to be spherical by SEM studies. In vitro release studies of pulsatile device revealed that, increasing the hydrophilic polymer content resulted in delayed release of trimetazidine from microspheres.
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Author(s): Anil KumarSN Chitagunta Pavanveena KavithaK Vinay kumarKV Arjun NC PuneethKP ShivarajA
Pulsatile, Chronopharmaceutics, Anginapectoris, Trimetazidine Hydrochloride