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Short Communication Open Access
Celecoxib, a non-steroidal antiinflammatory drug is poorly water soluble. In the present study a new dissolution medium was developed, as there is no official dissolution medium. The composition of the medium was selected on the basis of solubility data of celecoxib at 37Âº. Solubility data revealed that water consisting of 2% w/v sodium lauryl sulphate could be a suitable dissolution medium. The discriminating power of the selected dissolution medium (2% w/v sodium lauryl sulphate in water) relative to other dissolution mediums was evaluated and the results further justified the usage of 2% w/v sodium lauryl sulphate in water as dissolution medium for celecoxib.
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Author(s): G V Murali Mohan Babu V Gouri Shankar K Hima Sankar A Seshasayana N Kishore Kumar K V Ramana Murthy