alexa Abstract | Development of mesophasic microreservoir-based transdermal drug delivery system of propranolol

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

The mesophasic microreservoir comprises lyotrophic liquid crystals. The liquid crystals were prepared of Brij-35, cetosteryl alcohol and propranolol and evaluated for parameters viz. anisotropy, size and size distribution and drug entrapment efficiency. Subsequent to this liquid crystals based transdermal drug delivery system (TDS) was prepared by incorporating liquid crystals in previously prepared matrix based transdermal patch and evaluated for stability studies like temperature, humidity and aging. The system was also studied for tensile strength, moisture content, water vapor transmission, drug content, anisotropy and In vitro drug release studies.

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Author(s): LK Omray S Kohli AJ Khopade S Patil Asmita Gajbhiye GP Agrawal

Keywords

Liquid crystals, transdermal, drug delivery, In vitro evaluation, propranolol

 
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