alexa Abstract | Differential effects of H2 receptor antagonists on male reproductive function and hepatic enzymes in Wistar rats

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Histamine 2 (H2) receptor antagonists are clinically very useful drugs for the treatment of peptic ulcers. We undertook this study to investigate the effects of therapeutic and double therapeutic dose levels of H2 antagonists, cimetidine and ranitidine, on reproductive parameters and serum levels of hepatic enzymes in the Wistar rat. Cimetidine (30 or 60mg/kg/day), ranitidine (8 or 16mg/kg/day) and vehicle (1ml/kg/day) were administered to different animal groups (n=8) by gastric gavage for 14days. Animals were sacrificed and blood serum levels of alkaline phosphatase (ALP), aspartate transaminase (AST), and alanine transaminase (ALT) were measured. Epidydimal sperm and histological analyses of the testis were also performed using standard methods. Cimetidine and ranitidine had no significant (p>0.05) effects on ALP, AST and ALT levels. Ranitidine had no significant effect on all sperm and histological parameters evaluated. Cimetidine causedsignificant (p<0.05) and dose-dependent decreases in sperm count and motility, without an effect on sperm morphology and viability. Cimetidine also caused alterations in the histology of the testis. We conclude that subchronic administration of clinical dose levels of cimetidine may alter testicular function, possibly via direct adverse effects on the seminiferous tubules, while ranitidine may not. Cimetidine and ranitidine may not impair normal hepatic biochemical function.

To read the full article Peer-reviewed Article PDF image

Author(s): Aprioku JS Ibeachu C AmahTariah FS

Keywords

Cimetidine, histamine, spermatogenesis, spermatozoa

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us