alexa Abstract | Diffusion Tensor Scalars Vary with Age and Across Spinal Levels in Children

Journal of Neurology and Neuroscience
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Purpose: 1) To evaluate the maturational evolution of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the normal pediatric cervical as well as upper thoracic cord, 2) to evaluate whether ADC and FA values vary at different levels within the spinal cord [upper cervical (UC), lower cervical (LC) and upper thoracic (UT)].

Methods: Normal pediatric MRI and diffusion tensor imaging (DTI) studies of the spinal cord obtained with a 1.5 Tesla MR scanner were retrospectively analyzed. ADC and FA maps were reconstructed from the DTI data. Regions of interest were manually placed at the center of the cervical and upper thoracic cord at the intervertebral disk levels in mid-sagittal plane. The ADC and FA values were analyzed by linear regression and a general linear model with repeated measures.

Results: Forty-seven subjects ranged in age from 2 months-17.5 years (mean ± standard deviation: 74.3 ± 61.1 months) were included in the study. At all spinal cord levels a statistically significant decrease in ADC and increase in FA with increasing child’s age was evident. The ADC values of the UC/LC levels were higher than those of UT while the FA values did not show significant differences.

Conclusion: DTI scalars vary with age, likely due to ongoing maturational processes, and ADC values vary across levels of the spinal cord. Consequently when quantitative DTI of the spinal cord is undertaken in children; an age and levelmatched normative data should be used to accurately interpret the quantitative results.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Izlem Izbudak Netsiri Dumrongpisutikul Carol B Thompson Aylin Tekes Majda Thurnher andThierry AGM Huisman

Keywords

Apparent Diffusion Coefficient (ADC), Fractional Anisotropy (FA), Diffusion Tensor Imaging (DTI), Functional Neurology,Behavioral Neurology

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us