alexa Abstract | Distribution of the multidrug efflux pump genes adeA, adeI, adeJ, adeY and integrons in clinical isolates of Acinetobacter baumannii from Malaysian hospitals.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The objective of this study was to evaluate the incidence of multidrug resistance nodulationcell division pump (RND pump) genes and integrons in multidrug-resistant Acinetobacter baumannii isolated from in-patients in Malaysian hospitals. A total of 43 clinical isolates of A. baumannii were examined. All samples were found to be 100% resistant to ampicilin (n=43), ceftriaxone (n=43) and cefuroxime (n=43), followed by augmentin (n=40) and chloramphenicol (n=40) (93%). Local isolates of A. baumannii were also found to develop resistance towards the new class of antibiotic-tigecycline (58.14%). The presence of adeA, adeIJ, adeY RND efflux system genes and integrase gene was assessed by polymerase chain reaction (PCR). adeY was not detected in any of the samples. However, majority of the isolates (62.7%, n=27) carried adeA and adeIJ genes, but not integrase gene. Interestingly, the isolates harboring these genes also showed the highest level of resistance toward all antibiotics. In addition, 13.9% of the isolates (n=6) did not carry any of the RND genes; while class 1 integrons were only detected in three isolates (7%, n=3), in which all harbored the same gene cassette aacA4-catB8-aadA1. This suggests the possibility of higher usage of RND efflux pump genes in antibiotic resistance mechanism for local A. baumannii compared to integron genes. Besides, the co-presence of adeA and adeIJ genes also reveals their possible relationship for antimicrobial resistance in A. baumannii isolates.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): SueBee Kor BeatriceSingYieng Tou CorneliusKwangLee Chieng MicheleSookYuin HiewChoyHoong Chew

Keywords

Acinetobacter baumanii, RND efflux pump genes, Integrons, Multidrug resistance

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us