alexa Abstract | DNA Damage in Perinatal Asphyxia using Micronucleus Assay

Current Pediatric Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

This study was conducted to determine the level of DNA damage in perinatal asphyxia us-ing micronucleus(MN) assay and correlate with severity of asphyxia. Eighty term asphyxi-ated and sixty term non-asphyxiated neonates were enrolled in this case /control study. Blood samples were collected within 24 hours of birth for micronucleus assay and estima-tion of serum malondealdehyde (MDA). Micronucleus score was correlated with severity of asphyxia and serum MDA level. There was a significant difference of micronucleus (MN) score and serum MDA level in cases and controls (p value <0.0001). Among babies in vari-ous hypoxic ischemic encephalopathy ( HIE) stages the micronucleus score significantly in-creased with severity of asphyxia (p value <0.0001).There was a significant correlation be-tween Apgar score, HIE stages, seizures , micronucleus score and serum MDA level (p value <0.0001). Micronucleus score and serum MDA level correlated well with severity of asphyxia

To read the full article Peer-reviewed Article PDF image

Author(s): A Manoj K Ramachandra Rao BVishnu Bhat C VenkateshZachariah Bobby

Keywords

DNA damage, Micronucleus, MDA , Perinatal asphyxia

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us