alexa Abstract | Docking studies of Benzimidazole Schiff bases with Mycobacterium tuberculosis 3HNT Protein

Journal of Chemical and Pharmaceutical Research
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Abstract

The re-emergence of tuberculosis (TB) as a global health problem over the past few decades, accompanied by the rise of drug-resistant strains of Mycobacterium tuberculosis, emphasizes the need for discovery of new therapeutic drugs against this disease. The emerging serious problem both in terms of TB control and clinical management prompted us to synthesize a novel series of heterocyclic compounds and determine their activity against 3HNT protien of Mycobacterium. All compounds inhibited the growth of the 3HNT strain of mycobacterium at concentrations as low as 1 mg/mL

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Author(s): D Prabhakara Chary V Krishnaa R Premalathab and B Sandhya Ranib

Keywords

Lipoarabinomannan(LAM), M. tuberculosis, docking, Imidazolopyridine drugs, Schiff bases,Docking

 
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