alexa Abstract | Docking studies on fungal lectin for inducing tumor necrosis factor related apoptosis inducing ligand-receptor 2 (TRAIL-R2): Using Hex

European Journal of Experimental Biology
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Research Article Open Access


Tumor necrosis factor Related Apoptosis Inducing Ligand (TRAIL) is member of cytokines which induce apoptosis only on cancer cells, by binding with their receptors called TRAIL-R1 and TRAIL-R2. But almost all cancerous cells are resistance to TRAIL mediated apoptosis. Here we described the docking of fungal derived lectins for induction of TRAIL-R2. Four fungal lectins Sclerotinia sclerotiorum (SSL), Flammulia velutipes (FVL), Psathyrella velutina (PVL), Xerocomus chrysenteron (XCL) and TRAIL-R2 structure were derived from Protein Data Bank. The binding energy of fungal derived Lectins with TRAIL-R2 were estimated by using Hex 6.0 docking software. All fungal derived Lectin peptides were showed good binding energy, among them XCL showed excellent binding energy (-539.72). Further in vitro and in vivo study is needed to confirm the up regulation of TRAIL-R2, decipher to TRAIL

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Author(s): Sathishkumar Arumugam and Kalaiselvam Murugiyan


Anticancer, TRAIL, Docking

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