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Original Articles Open Access
Pyrazolo pyridazine are obtained by diazotization of substituted anilines followed by coupling to form corresponding hydrazones which on Intramolecular cyclisation forms 3-acetyl- substituted-cinnolin-4-ones. Further, treatment with hydrazine hydrate yields the expected 3’-methyl-substituted-pyrazolo [4, 3-C] Cinnoline derivatives. The compounds were characterized by analytical techniques like TLC, UV, IR, NMR Spectral studies. All the synthesised compounds were checked for drug likeliness using QIKPROP software and found to be efficacious and Screening for anti-tumor activity against breast cancer cell lines. The compound 1C was found to be safe and potent drug moderately incomparison to standard drug.
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Author(s): S Hurmath Unnissa and Shyaleen Rose
Pyrazolo pyridazine , Cinnoline, MCF-7 cell line, qikprop, Breast cancer, Drug design