alexa Abstract | Drug release from multiple w/o/w emulsions

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

The effect of some polyhydric alcohols and PVP, pH of the desorbing solution and viscosity of the emulsion on the release characteristics of salbutamol sulphate from a W/O/W multiple emulsion system was studied. The drug release profiles exhibited two phases, an initial fast phase, followed by a second, slower phase. The polyhydric alchols were found to increase drug diffusion with increasing concentration of additive while PVP had only a marginally higher effect. Drug release was dependent on the pH of the desorbing solution. The viscosity of the outer aqueous phase has a marginal effect on drug diffusion.



Author(s): JK Pandit B Mishra B Chand

 
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