alexa Abstract | Ductal Adenocarcinoma of the Pancreas with Psammomatous Calcification. Report of a Case

JOP. Journal of the Pancreas
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Context Calcification is extremely rare in pancreatic ductal adenocarcinomas, but we may sometimes encounter focal dystrophic calcification. Case report We herein report the case of an 83-year-old female with pancreatic ductal adenocarcinoma associated with diffuse psammomatous calcification. The calcification was preoperatively detected by computed tomography. Numerous psammoma bodies were scattered throughout the tumor. Immunohistochemical positivity of osteopontin, a non-collagenous bone-related protein, was found in the psammoma bodies. Conclusions The possibility of pancreatic ductal adenocarcinoma should therefore be considered for a localized calcified lesion in the pancreas. Therefore, osteopontin may play a significant role in the development of psammoma bodies. Studies to elucidate the prognostic significance of psammoma bodies in pancreatic ductal adenocarcinomas are therefore recommended.

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Author(s): Nobuyuki Ohike Masashi Sato Masaaki Kawahara Sho Ohyama Toshio Morohoshi


Adenocarcinoma, Calcinosis, Osteopontin, Pancreas, Tomography, X-Ray Computed

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