alexa Abstract | Effect of β Cyclodextrin complexation on the solubility and dissolution rate of carbamazepine from tablets

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Carbamazepine was complexed with β -cyclodextrin in an attempt to enhance the solubility features of the drug. Phase solubility studies revealed a linear relationship between carbamazepine solubility and b-cyclodextrin concentration. The value of the stability constant (405.42 M-1sub ) calculated from the phase solubility diagram indicated that the complexes were adequately stable. Carbamazepine-β -cyclodextrin complex prepared by kneading method was used to produce dispersible tablets. A 2 3sub factorial design was employed to investigate the effect of factors such as amount of binder, hardness and type of disintegrant on the tablet disintegration time and dissolution rate. Mathematical models containing only the significant factors influencing each response were generated using multiple linear regression and analysis of variance. The three main factors studied had a significant influence on both the response parameters. In addition to the main factors, the two-way interaction factors also showed a significant effect on the release rate. Type of disintegrant emerged as the main effect with the highest statistical significance affecting both the responses. Two formulations with a combination of factors within the experimental domain were developed and evaluated to validate the mathematical models. The predicted values were found to agree with the experimental values, confirming the forecasting ability of multi-linear regression and ANOVA.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Sarasija Suresh HN Shivakumar G Kiran Kumar

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us