alexa Abstract | EFFECT OF â -CYCLODEXTRIN ON PHYSICAL STABILITY OF NIMESULIDE SUSPENSION

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Stability of disperse systems is always a challenging task for formulator and thus assurance of physical stability of such system by proper evaluation is mandatory. The efficiency of suspension is related to the efficient dispersion of drug particles in the vehicle at the time of dosing. Patient compliance is difficult to assure, if redispersibility is poor. Present study shows the effect of ? -cyclodextrin on physical stability of nimesulide suspension which also includes formulation and evaluation. These formulations were evaluated for sedimentation volume, redispersibility, pH measurement, viscosity measurement, particle size, and drug content estimation at various time intervals for 3 months. It also includes DSC studies in order to assess the complexation with ? -cyclodextrin. Outcomes of all quality parameters suggest that nimesulide suspension formulations F4 i.e. drug: â -cyclodextrin with 1:1.5 ratio was optimum.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Panda Madhulita Patro Ganesh Malpani Amol Majji Sunil Rao Bhanoji M E

Keywords

Nimesulide, â-cyclodextrins, kneading, stability.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us