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The present study was aimed at investigating the effect of Cinnamomum zeylenicum bark oil on drug induced diabetic gastroparesis in rats. A diabetic rat model was established by single intraperitoneal injection with alloxan monohydrate. Rats were divided into five main groups: Normal rats, diabetic rats (Untreated), diabetic rats treated with domperidone (10mg/kg, p.o.), diabetic rats treated with cinnamomum oil (400mg/kg, p.o.) and diabetic rats treated with cinnamomum oil (200mg/kg, p.o.). Gastric emptying rate (GER), intestinal transit rate (ITR), and total gastrointestinal transit were studied in rat after administration of drug. Percentages of GER, ITR, and total gastrointestinal transit time were calculated. Percentages of GER, ITR, and total gastrointestinal transit were decreased in diabetic rats as compared to control rats (P < 0.05). In the diabetic rats, bark oil of Cinnamomum zeylenicum significantly improved %GER, %ITR and total gastrointestinal transit in a dose dependent manner. Bark oil of Cinnamomum zeylenicum may become a new choice for patients with diabetic gastroparesis since the benefits are comparable to domperidone.
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Author(s): Shipra Soni Pradeep Deshmukh Rupesh Soni Rahul Trivedi Anil K Gupta Narendra Silawat
Cinnamomum zeylenicum, Diabetic gastroparesis, Gastric emptying, Intestinal transit