alexa Abstract | Effect Of Cisplatin On Total Protein In Rat Kidney Cortical Slices

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Incubation of rat renal cortical slices with 3.3 mM cisplatin produced concentration – dependent decrease in total protein. The reduction in protein content was significant only after 30 min. To find out the role of reactive oxygen species (ROS), incubation was carried out in the presence of antioxidants. The water soluble analog of Vitamin E, trolox, protected the cortical slices against the cisplatin effect but ascorbic acid failed to produce any effect. Similarly, catalase and hydroxyl radical scavengers like dimethyl sulphoxide (DMSO), mannitol produced protection but superoxide dismutase (SOD) did not show protection. In conclusion, this study indicates that cisplatin causes decrease in the protein content in renal cortical slices and this decrease may be mediated through reactive oxygen species.

To read the full article Peer-reviewed Article PDF image

Author(s): Mahadev Rao M N A Rao

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords