alexa Abstract | Effect of composition of powder bed blends on the properties of granules and compacts in granulations containing surfactants.

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


Sulphanilamide, phenobarbitone and paracetamol as active ingredients, having varying aqueous wettability, were each investigated when subjected to variations in Lactose-based powder blends for tabletting. The influence of surfactants on the consistency of such blends was determined using wet granulation process. The surfactants, dioctyl sodium sulphosuccinate and cetrimide (0.01 to 0.5 w/w) were incorporated into binder solutions containing 5 percent w/w PVP. The effects of the surfactants on mean granule size, granule friability as well as compact hardness and disintegration times varied; Mean granule size decreased with easily wetted powder blends, but increased with poorly wetted powder blends; while granule friability was reduced. Resultant fall in compact hardness and disintegration times were observed with increased surfactant concentration. Whereas, in the absence of surfactants, poorly wetted powder blends produced smaller and more friable granules than powder blends that are readily wetted. The effect of decreasing the wettability of the powder bed blend generally produces stronger compacts.

Author(s): F Oyewo N Mbang Olatunji M Folashade

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version