alexa Abstract | Effect of Dipeptidyl Peptidase-4 Inhibitors on Adenosine Deaminase Activity in Type-2 Diabetes Mellitus.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Immunological disturbances in T2DM have an association with CMI and an inappropriate immune response may result from the defects in the action of insulin that is required for Tlymphocyte function. ADA, an enzyme distributed in human tissues, is considered a good marker of CMI as well as a marker for insulin function. Dipeptidyl peptidase - 4 (DPP- 4) also known as adenosine deaminase binding protein (ADABP) binds with ADA to activate T lymphocytes. DPP4 inhibitors are currently regarded as potential oral drugs for the treatment of T2DM and have shown improved efficacy over time. This study was conducted in order to make a contribution to the understanding of the effect of DPP-4 inhibitors on the ongoing immune disturbances in T2DM by analysing their serum ADA level and comparing the effect of other commonly prescribed oral anti-diabetic drugs on the activity of this enzyme. A group of 96 newly diagnosed T2DM patients on oral hypoglycemic medication and 46 healthy non-diabetics were enrolled as cases and controls, respectively. 50 subjects were taking a combination drug comprising of SU +Met (Group 1) and 46 were taking an add on DPP-4 inhibitor (Group 2). Serum ADA activity was investigated in the whole study group. It was found to be significantly decreased in group 2 as compared to group 1. A positive correlation between the enzyme activity and HbA1c levels was observed in these patients (Group 2) as well, when compared to cases on other oral anti-diabetic drugs (Group 1) indicating the ability of DPP-4 inhibitors to significantly alter the immune status along with the glycemic status in T2DM.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Sumit Jhajharia Tapaswini Pradhan Anjana Ekka Ashok Kumar Das

Keywords

Type 2 Diabetes Mellitus (T2DM), Cell mediated immunity (CMI), Adenosine Deaminase (ADA), Dipeptidyl peptidase – IV(DPPIV) Inhibitors, Sulfonylurea (SU), Metformin (Met).

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us