alexa Abstract | Effect of fraction 1 of Portulaca oleracea on plasma gonadotrophins and testosterone levels and their recoveries in male wistar rats

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Portulaca oleracea is a fleshy annual herb which is distributed throughout temperate and tropical areas of world. Crude extracts of this plant caused significant decreases in testosterone levels in male rats. Air-dried specimen of Portulaca oleracea was cold-extracted in methanol for 72 hours. The resulting methanol extract was then subjected to open column chromatography for fractionation. Out of 5 fractions obtained, fraction 1 was then subjected to male rats’ hormonal bioassays. Twenty male rats were divided into control and fraction 1 (1, 2, 3 mg/kg) treated groups for hormonal assay study. The animals were orally treated on daily basis for 50 days and allowed a recovery (withdrawal) period of 50 days after which hormonal assays were carried out at the end of dosing and recovery periods. Plasma LH, FSH and testosterone levels were assayed using Enzyme – Linked Immunosorbent Assay (ELISA) technique. Treatment of rats for 50 days with fraction 1 (1 mg/kg, 2 mg/kg, 3 mg/kg) caused significant (p<0.05) decreases in LH levels but caused no significant (p>0.05) changes in FSH levels relative to their respective controls. Fraction 1 (1 mg/kg, 2 mg/kg, 3 mg/kg) caused significant (p<0.05) increases in testosterone levels relative to control. There were significant (p<0.05) reductions in FSH levels of fraction 1 (1 mg/kg, 2 mg/kg and 3 mg/kg) recovery groups relative to control. It can therefore be concluded that fraction 1 of Portulaca oleracea probably induced significant changes on plasma gonadotrophins and testosterone levels through hypothalamic – pituitary testicular axis which could result in irreversible sterility.

To read the full article Peer-reviewed Article PDF image

Author(s): Oyedeji K Olusina Adegoke Olajire Oladosu I Adebayo and Oni J O

Keywords

Fraction 1, Testosterone, Luteinizing hormone (LH), Follicle stimulating hormone (FSH), Rats.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords