alexa Abstract | Effect of gamma irradiation on the antitumor activity of newly synthesized of copper (II) complexes of thiosemicarbazone derivatives

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Cancer is undoubtedly one of the main health concerns facing our society and one of the primary targets regarding medicinal chemistry. Thiosemicarbazones and their metal complexes are compounds that possess antitumor, antibacterial, antifungal and antiviral properties. In this study, a series of copper complexes of 2- anilinophenyisothiocyanate semicarbazone has been prepared and phyico-chemical characterized by elemental analysis, infrared spectroscopy (IR), Electronic spectra, magnetic moment, molar conductance measurements and X-ray diffraction pattern. The IR data before and after γ- irradiation revealed that the ligand behaves as neutral, monobasic bidentate coordination of copper ion via the carbonyl group or enolic oxygen group, NH group and thiol sulphr atom group in complex B2. The molar conductance data revealed that the chelates are nonelectrolytes. From the spectra and magnetic moment data, the complexes were found to have square planar geometrical structures. The antitumor activities of these compounds were investigated against solid tumor induced in mice by injection of Ehrlich Ascites Carcinoma (EAC) cell line. Results revealed that tested compounds significantly reduced the tumor size. Gamma-irradiated compounds showed potent antitumor activities when compared to that of non-irradiated compounds. In addition, tested compounds exhibited stimulatory effect on the level of catalase and superoxide dismutase activities and glutathione content in liver of tumor bearing mice, while the level of lipid peroxidation was significantly reduced. It is concluded that thiosemicarbazone complexes and lignad are considered as promising anticancer drugs candidate. Moreover, the γ-irradiation evokes the antitumor activity of the tested compounds.

To read the full article Peer-reviewed Article PDF image

Author(s): Samar A Aly Hussien H Alganzory and Tarek A Salem

Keywords

Antitumor activity, Antioxidant enzymes, γ-irradiation Thiosemicarbazone complexes, antitumor

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords