alexa Abstract | Effect of levofloxacin and 3-carboethoxy-4-quinolone on the b-amyloid fibrils formation

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Alzheimer´s disease (AD) is a progressive and irreversible neurological disorder associated with age-related dementia. Extracellular deposition of fibrils derived from b-amyloid peptide (Ab) is one of the most important pathological hallmark of AD. Here we present results concerning the investigation of the in vitro inhibitory effect of the quinolones levofloxacin (3) and 3-carboethoxy-4-quinolone (4) on the Ab fibrillation. A b 42 peptide solutions were incubated in the presence of either compound 3 or 4 and the fibrillation was assessed by thioflavin-T fluorescence assay and atomic force microscopy (AFM). The results indicate that compounds 3 and 4 are inhibitors of Ab fibrillization, being the latter more potent. Quinolone 4 also promotes the disaggregation of pre-formed Aβ fibrils. We concluded that both compounds interfere with the fibrillization process.

To read the full article Peer-reviewed Article PDF image

Author(s): Paula Cristina Huber Gabriella Pitondo Reis Carlos Eduardo Benevento Roger Frigrio Castilho and Wanda Pereira Almeida

Keywords

Alzheimer´s disease, b-amyloid, levofloxacin, quinolones, fibrillation, levofloxacin

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords