alexa Abstract | Effect of Nigella sativa on experimental liver fibrosis.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Our objective was to investigate the effects of NS, Nigella Sativa oil (NSO) and thymoquinone (TQ) on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. Our study groups consisted of five subgroups: the control, DMN, TQ, NS, and NSO groups. At the end of the study, the animals were sacrificed, and blood and tissue samples were obtained. Malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and routine biochemical parameters were analyzed. Histopathologic evaluation of the NS, NSO and TQ groups found normal liver tissue and short fibrosis, and fibrous expansion with or without a septum and in some portal areas. The DMN group evaluation found incomplete cirrhosis in the liver tissues of rats. While erythrocyte and tissue MDA levels were higher, SOD and GSH-Px activities were lower in the NS, NSO and TQ groups when compared to the DMN group. Our results showed that NS and its components reduced oxidative stress and had antioxidant effects and free-radical scavenging activity. NS also protected the antioxidant enzyme activities in the liver tissue of rats.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Edibe Saricicek Mehmet Tarakcioglu Vahap Saricicek Murat Taner Gulsen Metin Karakok Yasemin Baltaci Seyithan Taysi


Nigella Sativa, Nigella Sativa Oil, Thymoquinone, Liver Fibrosis

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version