alexa Abstract | Effect of Nitazoxanide on cardiovascular system, respiratory system and nervous system

Journal of Chemical and Pharmaceutical Research
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Abstract

Nitazoxanide, a thiazolidine compounds, is an efficient, broad-spectrum anti-parasitic and anti-microbial drug. On the one hand, by measuring breathing rate, breathing extent and electrocardiogram, effect of nitazoxanide on cardiovascular system and respiratory system of anesthetized rats was tested. On the other hand, by observing the activities and behavior change of mice, conducting climbing pole test and muscle fatigue test, the effect of nitazoxanide on nervous system was obtained. Results indicated that in the dose range 100mg-400mg/kg, nitazoxanide affected little to cardiovascular system and respiratory system of anesthetized rats and did not significantly inhibit central nervous system of mice.

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Author(s): Yanchun Gao Zhihui Hao Kefeng Xiao Leilei Wang Li Zhao and Qidi Zhang

Keywords

nitazoxanide, safety pharmacology, cardiovascular system, respiratory system, nervous system, Nitazoxanide

 
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