alexa Abstract | Effect of Olive Leaf Components on the Expansion of Human Hematopoietic Stem and Progenitor Cells.

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Hematopoietic stem cells (HSCs) transplantation and/or the infusion of hematopoietic cells are currently the best alternative for the treatment of a wide variety of hematological disorders. Novel modulators of HSCs fate continue therefore to be identified in an attempt to optimize the in vitro culture of these cells. In this study, main olive leaf components, oleuropein, apigenin 7-glucoside, and luteolin 7-glucoside, and their combination, were investigated for their effect on the viability, self-renewal and differentiation of CD34+ hematopoietic cells. High concentrations of up to 50 μM of these olive leaf phytochemicals, as well as their combination, did not decrease CD34+ cell viability suggesting that these compounds are not cytotoxic on HSCs. Flow cytometric analysis revealed a decrease in the expression of CD34 on the cell surface of HSCs after 9 days of treatment with these compounds indicating a decrease in the proportion of the stem population. Results of the colony-forming unit assay showed an increase in the number of different colonies following treatment with olive leaf phytochemicals. These findings suggest that olive leaf phytochemicals, used alone or in combination, enhance the differentiation of hematopoietic stem cells rather than stimulating their self-renewal providing the first evidence of the potential differentiation effect of main olive leaf compounds on HSCs.

To read the full article Peer-reviewed Article PDF image

Author(s): Samet I Villareal MO Han JH Sayadi S Isoda H

Keywords

Hematopoietic stem cells, olive leaf components, cell viability, self-renewal, differentiation.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords