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Research Article Open Access
The aim of this work was to evaluate the presence of antibacterial properties in a plasmin digest of bovine ÃÂ-casein. Although native bovine κ-caseinis resistant to plasmin, extensive hydrolysis of this milk protein was observed applying a long incubation period. The antibacterial potential of κ-casein, plasmin, PDÃÂ was evaluated against pathogenic (Escherichia coli and Staphylococcus aureus) and probiotic (Lactobacillus casei and Lactobacillus acidophilus) bacteria in vitro. Although ÃÂ-casein and plasmin had no antibacterial activity, PDÃÂ showed antibacterial property against the tested bacteria. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of PDÃÂ was determined for the target bacteria. The MIC and MBC of PDÃÂ against Escherichia coli was considerably higher than Staphylococcus aureus, Lactobacillus casei and Lactobacillus acidophilus bacteria. The growth curves alterations of target bacteria in the presence of PDÃÂ were monitored by turbidimetry in broth culture. The effect of PDÃÂ on lag time and maximum absorbance was more significant than slope of tested bacteria. In addition of growth curves, PDÃÂ has inhibitory effects on the plate count confirmation of tested bacteria. The maximum inhibitory effect of PDÃÂ was created in MIC concentration.
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Author(s): Marjaneh Sedaghati Hamid Ezzatpanah Massod Mashhadi Akbar Boojar Maryam Tajabadi Ebrahimi and Mehdi Aminafshar
Bovine, K-casein, Antibacterial, Plasmin, Growth curve