alexa Abstract | Effect of seeding on sucrose polymorphism

Journal of Chemical and Pharmaceutical Research
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Abstract

The study of polymorphism in pharmaceutical compounds and their intermediates is very important and an integral part of drug development in present days. In fact, a detailed polymorphic study helps to resolve problems such as drug solubility and drug formulation techniques in drug manufacturing processes. The subject of polymorphism has received extensive academic and industrial attention. The regulatory requirements for filing new drug application (NDA) and abbreviated new drug application (ANDA) of a particular dosage form are so stringent that pharmaceutical companies are bound to study polymorphs along with their bioavailability and stability. The present study demonstrates the effect of seeding on the polymorph of sucrose which is used as a drug when complexed with iron as in Iron-Sucrose or in the form of excipient.

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Author(s): Runjhun Tandon and Nitin Tandon

Keywords

PXRD, Polymorph, ANDA, NDA, Seeding, polymorphism

 
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