alexa Abstract | Effect of supplementation of black tea extract on indomethacin induced alteration of pathophysiology of rat liver

Journal of Chemical and Pharmaceutical Research
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Cyclooxygenase-2 (COX-2) expression and prostaglandin production are suggested to play important, complex roles in the pathogenesis of various liver diseases. Indomethacin generates free radicals and induce oxidative and nitrosative stress with depletion of antioxidants. In this study, we have evaluated the beneficial effects of black tea extract against indomethacin induced liver toxicity. We studied the effect of supplementation of Black tea extract (BTE, 2.5 g tea leaf/dL of water, i.e., 2.5% of aqueous BTE, orally) on indomethacin (5mg/kg body weight, i.p.) induced liver oxidative and nitrosative stress in Wister strain male albino rats. Hematological parameters, serum nitric oxide, L-ascorbic acid and serum malondialdehyde concentrations were evaluated. We also evaluated total protein, SGOT, SGPT and histopathology of liver. Indomethacin treated rats showed significantly decreased body weight, hepatosomatic index, hematological parameters, L-ascorbic acid concentrations, nitric oxide, total protein levels and increase in malondialdehyde SGOT and SGPT parameters as compared to their controls. However, simultaneous treatment with indomethacin and black tea extract produced a remarkable improvement of all the above parameters when compared with treatment with indomethacin drug alone. However, simultaneous treatment with indomethacin and black tea extract significantly improve the serum nitric oxide, L-ascorbic acid and malondialdehyde concentrations, as compared to indomethacin treatment alone. Histopathology of the liver revealed swollen hepatocyte, foci of fatty changes and ballooning degeneration in indomethacin treated rats which almost reverse back in BTE supplemented indomethacin group. Results indicate that BTE is beneficial in preventing NSAID induced hepatocellular damages.

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Author(s): Ishwar B Bagoji J G Jargar S M Yendigeri M A Doshi B G Patil and K K Das


Indomethacin, free radicals, black tea extract, antioxidants, liver histopathology, pathophysiology

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