alexa Abstract | Effect of the Addition of Hand-Mixed Generic Vancomycin on Bone Cement Strength

Annals of Clinical and Laboratory Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Background: No literature up to date has investigated on the mechanical strength of hand-mixed Vancomycin cement spacers. This puts to question the reliability of such practice in creating the spacers for load support in addition to Methicillinresistant Staphylococcus aureus (MRSA) coverage.

Objective: The study compared the mechanical strength of hand-mixed generic Vancomycin bone cement with standard non-antibiotic bone cement.

Methods: One (1) gram vials of generic Vancomycin powder were dry-blended with the cement powder (Cemex) following standard aseptic hospital practice (1 g Vancomycin in 40 g of cement powder). Samples for the cement-alone group were done similarly except for the addition of the antibiotic powder. Tensile and compression samples were created, soaked in saline, and stored at 37 degrees Celsius for one week. All samples were tested at the University of the Philippines College of Engineering Mechanical Laboratory for compressive and tensile strength. Acceptance or rejection of the null hypothesis was conducted using the t-test procedure performed on Minitab 15 Trial Version, with α of 0.05 as the level of significance.

Results: T-test analysis performed on compressive strength data produced a p-value of 0.944 (α of 0.05), and on tensile strength data, 0.311 (α of 0.05).

Conclusion: There is no effect of the addition of hand-mixed generic Vancomycin on the mechanical properties of the bone cement.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Mamer S Rosario and Venancio P Garduce


Vancomycin, Methicillin-resistant Staphylococcus aureus, Bone cement, Anesthesia Research, Bone cancer, Staphylococcus aureus Infection

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us