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Research Paper Open Access
Effects of high doses of vitamin A on the biochemical parameters of the adrenal gland of 10 d to 40 d old Swiss albino mice were studied by measuring total protein and cholesterol content, acid phosphatase and alkaline phosphatase enzyme levels. The animals were divided into four different age groups for both control and test groups. Control groups did not show any significant change in total protein amount, cholesterol content, acid phosphatase and alkaline phosphatase during the entire period of study. Total protein and cholesterol content of test groups decreased significantly at higher dose levels of vitamin A. Acid phosphatase and alkaline phosphatase contents were elevated at each dose level. The result of this study revealed that vitamin A is responsible for stimulation of adrenal gland activity through increased corticoid synthesis and membrane permeability.