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The effects of lead on sera glucose, protein and cholesterol concentrations and on hematocrit levels of Anguilla anguilla exposed to 0.06 and 0.12 ppm lead were studied over 15 and 30 days. Sera parameters and hematocrit levels were determined by spectrophotometric and microhematocrit methods, respectively. No mortality was observed during the experiments. Sera glucose and protein levels showed a linear increase and a decrease respectively under the effect of lead. Sera cholesterol levels decreased compared to control over 15 days of exposure to both concentrations and this decrease was not significant between the concentrations on day 30. Lead concentrations 0.12 ppm lead did not cause any variation in hematocrit level, while 0.06 ppm lead increased it compared to control.. Changes in sera parameters and hematocrit levels of A. anguilla under the effect of lead can be attributed to restoration of homeostasis against the stress conditions caused by the metal.