alexa Abstract | Effects of Smilax myosotiflora on testicular 11?-hydroxysteroid dehydro-genase oxidative activity and plasma hormone levels in rats

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Smilax myosotiflora, a popular local aphrodisiac is known to increase sexual libido. How-ever, the aphrodisiac efficacy of S. myosotiflora has not yet been scientifically established. Present investigation describes the effects of S. myosotiflora on testicular 11β-hydroxysteroid dehydrogenase (11β-HSD) oxidative activity and the levels of plasma corticosterone and tes-tosterone. Male Wistar rats (200-250g) were given either 8 mg/kg BW/day of S. myosotiflora or 120 μg/kg BW/day of Mifepristone (RU486, a glucocorticoid receptor (GR) antagonist) or both together (RU486+S. myosotiflora), for seven consecutive days. Results between groups were analyzed using analysis of variance (ANOVA) and Student’s t test. Differences were considered significant at P<0.05. Rats given S. myosotiflora showed no significant changes in 11β-HSD activity but had increased corticosterone (P<0.01) and decreased testosterone (P<0.01) levels compared to controls. Administration of RU486 alone decreased 11β-HSD activity (P<0.001), but increased testosterone levels (P<0.05) compared to controls. Con-versely, rats with RU486+S. myosotiflora showed increased 11β-HSD activity (P<0.001) but decreased testosterone levels (P<0.05) compared to RU486-treated rats. In the rats treated with RU486+S. myosotiflora, none of the parameters differed significantly from controls. Plasma corticosterone levels were found to be lowered in rats treated with RU486+S. my-osotiflora compared to S. myosotiflora-treated rats (P<0.05) towards control values. In this study, S. myosotiflora at a dose of 8 mg/kg BW/day was found to increase corticosterone with a corresponding decrease in testosterone levels. Previous studies show that RU486 acts through GR in affecting 11β-HSD activity and hormone levels. Since RU486+S. myosotiflora rats show opposite effects from RU486 rats, we therefore suggest that the actions of S. my-osotiflora on these parameters are possibly mediated through the GR. S. myosotiflora and RU486 probably competitively inhibit each other at the GR level.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Damayanthi D Azman MAB Aminuddin AHK Hamid A and Nwe KHH


Smilax myosotiflora, Testicular 11β-HSD, Plasma corticosterone, Plasma testosterone

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version