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Depressive disorders are amongst the most common life threatening disorders and despite of extensive research work its etiology and mode of action of antidepressant drugs remains elu-sive. The present study was conducted on 15 adult albino rats (200-250gm) divided into con-trol and experimental groups. First group was control, second group received acute depres-sion (4 weeks) by immobilization method using rat immobilizer and third group received standard 4 week treatment (using Flouxetine 1mg/kg body wt. orally) following acute de-pression. At the end of the experiment animals were sacrificed and perfused with 10% for-maldehyde. Brains were dissected and tissue blocks were processed for paraffin embedding. Observations were made on 10 micron thick H & E stained sections. Estimation of neuronal density of CA3 regions was performed using Motic images plus 2.0 Software. Neuronal den-sity was markedly reduced (100.3 cells/cubic mm) after acute depression, as compared to control (144.5 cells/cubic mm) and after standard treatment it improved to 121.1 cells /cubic mm. These results suggested that effect of short-term stress-induced depression on hippo-campus is partly reversed by the pharmacological intervention of known antidepressants and warrants longer term study.
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Author(s): Nazim Nasir and Aijaz Ahmed Khan
Hippocampus, Stress, Depression, Antidepressants, Neurogenesis