alexa Abstract | Efficacy of parsley (Petroselinum crispum) leaves extract and decoction on status of lipid profile and osmotic fragility in gentamicin-induced nephrotoxicity in rats

Journal of Chemical and Pharmaceutical Research
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Abstract

The clinical usefulness of gentamicin is limited due to the development of nephrotoxicity. The abnormalities in lipid and lipoprotein pattern produce number of pathological diseases including nephrotoxicity. Reactive oxygen species produce cellular injury and necrosis via several mechanisms including peroxidation of membrane lipids, protein denaturation, and DNA damage. Potential therapeutic approaches to protect (or) reverse GM damage would be having very important clinical consequences in increasing the safety of the drug. Several natural agents have been used to ameliorate drugs toxicity. The survey of literature reveals that the parsley (Petroselinum crispum) are found to be used in the traditional system of medicine. In addition, the aqueous extract of parsley reduced the number of calcium oxalate deposits and therefore parsley can be used for kidney and bladder stones. However, the nephroprotective and antidyslipidemic effect of P.crispum has not been scientifically investigated. So, the present study was design to evaluate the efficacy of parsley (P.crispum) extract and decoction on the kidney of gentamicininduced nephrotoxicity in rats. Freshly prepared ethanolic extract and decoction of P.crispum (PCE and PCD) were orally administered to rats. The altered renal markers (Urea, uric acid, creatinine and BUN) after GM administered were normalized in extracts treated animals. The modified levels of lipid profiles (total cholesterol, triglycerides, phospholipids, HDL, LDL, and VLDL) in GM administered rats were normalized in PCE and PCD treated animals. The membrane stabilizing effects were confirmed by erythrocytes osmotic fragility and to RBC morphology. In conclusion, this study revealed that PCE and PCD administered at a dose of 250mg/kg.bwt and 250mg/kg.bwt were effective respectively. Further, the results of the present study indicate that P.crispum may emerge as a putative nephroprotective, antihyperlipidemic and membrane-stabilizing agent against nephrotoxicity. Further studies need to be undertaken in order to confirm these findings and its extrapolation in humans

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Author(s): Abdullah Ahmad Jarllah Alkhalaf Saleh Abdulrahman Alrusayni Albaraa Khalid Abdulkarim Aloraifi Omar Ali Abdullah ALShammari and Sasikumar Dhanarasu

Keywords

Petroselinum crispum, gentamicin, nephrotoxicity, RBC and antihyperlipidemic, osmotic fragility, membrane-stabilizing agent, leaves extract

 
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